Welcome to the NFL Week 4 Preview. As the season enters its fourth week, injuries are piling up, playoff hopes are taking shape, and betting markets are shifting. Below is a complete breakdown of every matchup, from Thursday Night Football to Monday Night Football.
🏈 Thursday Night Football
Cardinals at Seahawks
The Cardinals are without James Conner (foot) and Zay Jones (concussion protocol). Seattle has the advantage at home, one of the loudest venues in football.
🌍 Sunday Morning (International Game)
Vikings at Steelers
Minnesota meets Pittsburgh in Dublin, Ireland, giving fans an early international kickoff. The Vikings’ offensive line has been shaky, while the Steelers’ defense thrives on pressure.
🔥 Sunday Early Window
Commanders at Falcons
Atlanta was shut out in Week 3 and now faces injury concerns. Jaden Daniels and Terry McLaurin both carry knocks into this matchup.
Saints at Bills
Buffalo’s defense will test Spencer Rattler, who needs to avoid costly turnovers. The Bills’ home-field advantage should tilt the game.
Browns at Lions
Detroit is rolling while Cleveland showed fight last week. The Lions’ pass rush should be the deciding factor.
Panthers at Patriots
Both offenses are struggling. Expect a low-scoring game where turnovers and field position matter most.
Chargers at Giants
The Chargers’ defense is banged up, and rookie QB Jaxson Dart makes his first start. The Giants’ pass rush could cause big problems.
Eagles at Buccaneers
Tampa Bay’s receivers are depleted with Mike Evans sidelined and Chris Godwin not fully healthy. Philadelphia’s roster depth gives them the edge.
Titans at Texans
A divisional battle between two inconsistent offenses. Houston’s red-zone efficiency may be the difference.
49ers at Jaguars
San Francisco is decimated by injuries — Nick Bosa, George Kittle, and Brandon Aiyuk are all out. Jacksonville has the chance to capitalize.
⚡ Sunday Late Window
Ravens at Chiefs
The headline matchup of Week 4 features Patrick Mahomes vs Lamar Jackson. Kansas City is short on weapons, but Arrowhead remains a fortress.
Bears at Raiders
Chicago’s offense clicked last week, while the Raiders’ Geno Smith continues to be turnover-prone.
Rams at Colts
The Colts rely on Jonathan Taylor, while the Rams’ discipline and ability to dictate tempo make them dangerous.
⭐ Sunday Night Football
Packers at Cowboys
Dallas is without CeeDee Lamb and two offensive linemen, but the big storyline is Micah Parsons returning to face his former team. Green Bay has a history of success in Dallas.
🌙 Monday Night Football
Jets at Dolphins
Miami’s offense has been inconsistent, while the Jets are still adjusting post-Rodgers. The Dolphins’ speed could be the deciding factor.
Bengals at Broncos
Cincinnati is without Joe Burrow, which severely limits their offense. Denver, playing at altitude, has the edge with rookie QB Bo Nix settling in.
✅ Final Takeaways
- Injuries are defining Week 4, with star players sidelined across multiple teams.
- The Cardinals vs Seahawks opener favors Seattle.
- The Vikings vs Steelers game in Dublin adds international flavor.
- Upset potential lies with the Giants and Bears.
- Primetime matchups — Chiefs vs Ravens, Packers vs Cowboys, and Jets vs Dolphins — headline the week.
